医师资格证
在线问诊
王坚，男，临床医学博士，教授/主任医师，博士研究生导师。复旦大学附属华山医院神经内科副主任。美国匹兹堡大学“帕金森病及其它神经变性病研究中心”博士后。长期聚焦帕金森病临床及基础研究、慢病长程管理。
社会任职
1.国际帕金森病及运动障碍协会(MDS) “Web Editorial Board”专家委员会委员
2.国家神经疾病医学中心(华山)功能神经疾病中心主任，
3.国家老年疾病临床医学研究中心(华山)“神经退行性疾病”研究方向负责人
4.中华医学会神经病学分会全国委员
5.中国康复医学会帕金森病和运动障碍专业委员会副主任委员
6.“中国e帕联盟”及“帕为帕金森病慢病管理APP平台”理事长
获奖荣誉
亚太MDS-AOS 2019 AOPMC年会Blue Ribbon Highlight奖
科研成果
共发表SCI文章140篇，论文共被引用4100+次，H指数39(Google Scholar)。2020年以来以通讯/第一（含共同）作者发表SCI研究成果41篇，包括Brain(2), JAMA Neurol, Cell Res, Nat Commun, Mov Disord(6), JNM, EJNMMI, NPJ Parkinsons Dis(2)。主持重大(培育)、面上、青年等国自然基金共7项，主持科技部国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项“帕金森病分子影像学研究”、 国家卫健委国家临床重点专科建设项目-功能神经疾病智能综合管理和诊疗体系建设、及多项省部级课题。
2020年以来发表的部分代表性成果：
1. Shen Y#, Yu WB#, Shen B#, Dong H, Zhao J, Tang YL, Fan Y, Yang YF, Sun YM, Luo SS, Chen C, Liu FT, Wu JJ, Xiao BG, Yu H, Koprich JB*, Huang ZL*, Wang J*. Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice. Brain 2020. 143:3374-3392.
2. Liu FT#, Lu JY#, Li XY#, Jiao FY, Chen MJ, Yao RX, Liang XN, Ju ZZ, Ge JJ, Li G, Shen B, Wu P, Song J, Li J, Sun YM, Wu JJ, Yen TC, Luo JF, Zhao QH, Zuo C*, Wang J*, Progressive Supranuclear Palsy Neuroimage I: (18) F-Florzolotau Positron Emission Tomography Imaging of Tau Pathology in the Living Brains of Patients with Corticobasal Syndrome. Mov Disord 2023. 2023-04-01;38(4):579-588.
3. Tang Y#, Han L#, Li S#, Hu T, Xu Z, Fan Y, Liang X, Yu H, Wu J, Wang J*: Plasma GFAP in Parkinson's disease with cognitive impairment and its potential to predict conversion to dementia. NPJ Parkinsons Dis 2023, 2023-02-09;9(1):23.
4. Sun YM#, Zhou XY#, Liang XN#, Lin JR#, Xu YD, Chen C, Wei SD, Chen QS, Liu FT, Zhao J, Tang YL, Shen B, Gan LH, Lu B, Ding ZT, An Y*, Wu JJ*, Wang J*: The genetic spectrum of a cohort of patients clinically diagnosed as Parkinson's disease in mainland China. NPJ Parkinsons Dis 2023, 9:76.
5. Liu FT#, Lu JY#, Li XY#, Liang XN, Jiao FY, Ge JJ, Wu P, Li G, Shen B, Wu B, Sun YM, Zhu YH, Luo JF, Yen TC, Wu JJ, Zuo CT*, Wang J*. 18F‐Florzolotau PET imaging captures the distribution patterns and regional vulnerability of tau pathology in progressive supranuclear palsy. EUR J NUCL MED MOL I. 2023-04-01;50(5):1395-1405.
6. Tang YL#, Li L#, Hu TY#, Jiao FY, Han LL, Li SY, Xu ZH, Fan Y, Sun YM, Liu FT, MD, Yen TC, Zuo CT*, Wang J*. In Vivo 18F-Florzolotau Tau Positron Emission Tomography Imaging in Parkinson’s Disease Dementia. Mov Disord 2022. DOI: 10.1002/mds.29273
7. Zhou XY#, Lu JY#, Liu FT, Wu P, Zhao J, Ju ZZ, Tang YL, Shi QY, Lin HM, Wu JJ, Yen TC, Zuo CT*, Sun YM*, Wang J*. In Vivo 18F‐APN-1607 Tau Positron Emission Tomography Imaging in MAPT Mutations: Cross‐Sectional and Longitudinal Findings. Mov Disord 2022, 37:525-534.
8. Liu FT#, Li XY#, Wu P, Li L, Liang XN, Ju ZZ, Chen MJ, Ge JJ, Sun YY, Wu JJ, Yen TC, Zuo CT*, Wang J*. 18F-Florzolotau tau PET imaging in patients with multiple system atrophy-Parkinsonian type. Mov Disord. 2022. 37(9):1915-1923.
9. Fan Y#, Zhao Q#, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C*, Wang J*, Li D*. Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Res 2022,0:1-4. 10.1038/s41422-022-00665-3.
10. Wu P#, Zhao Y#, Wu J, Brendel M, Lu J, Ge J, Bernhardt A, Li L, Alberts I, Katzdobler S, Yakushev I, Hong J, Xu Q, Sun Y, Liu F, Levin J, Hoeglinger G, Bassetti C, Guan Y, Oertel WH, Weber WA, Rominger A, Wang J*, Zuo C*, Shi K. Differential diagnosis of parkinsonism based on deep metabolic imaging indices. J Nucl Med 2022. J Nucl Med 2022, 2022-11-01; 63(11):1741-1747.
11. Li L#, Liu FT#, Li M, Lu JY, Sun YM, Bao WQ, Chen QS, Li XY, Zhou XY, Guan YH, Wu JJ, Yen TC, Jang MK, Wang J*, Zuo CT*, and the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). Clinical utility of 18F-APN-1607 tau PET imaging in patients with progressive supranuclear palsy. Mov Disord 2021,36:2314-2323
12. Sun YM#, Yu HL#, Zhou XY, Xiong WX, Luo SS, Chen C, Liu FT, Zhao J, Tang YL, Liang XL, Yang YJ, Shen B, Shen Y, Yu WB, Ding ZT, An Y*, Wu JJ*, Wang J*. Disease Progression in Patients with Parkin-related Parkinson's Disease in a Longitudinal Cohort. Mov Disord 2021;36:442-448.
13. Liu FT, Wang J*, Chen Y*: Lost Dopaminergic Bindings in the Caudate of a Patient With Frontotemporal Lobar Degeneration-Motor Neuron Disease. JAMA Neurol 2020, 77:1448-1449.
14. Guo M#, Wang J#, Zhao Y, Feng Y, Han S, Dong Q*, Cui M*, Tieu K: Microglial exosomes facilitate alpha-synuclein transmission in Parkinson's disease. Brain 2020. 143:1476-1497.
15. Lou MM, Tang XQ, Wang GM, He J, Luo F, Guan MF, Wang F, Zou H, Wang JY, Zhang Q, Xu MJ, Shi QL, Shen LB, Ma GM, Wu Y, Zhang YY, Liang AB, Wang TH, Xiong LL, Wang J*, Xu J*, and Wang WY*. Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons. Nat Commun 2021, 12: 4075-4092.
16. Wang Z#, Dong H#, Wang J, Huang Y, Zhang X, Tang Y, Li Q, Liu Z, Ma Y, Tong J, Huang L, Fei J, Yu M*, Wang J*, Huang F*: Pro-survival and anti-inflammatory roles of NF-kappaB c-Rel in the Parkinson's disease models. Redox Biol 2020, 30:101427.
